Benet (25-5) needed that attitude to overcome tall and athletic Simeon (20-11), the Chicago Public League runner-ups with multiple Division I prospects on its roster.
Prasse scored 15 points, Schramek and Stack had 13 each and Lindsey Rogers seven points – all in the second half – off the bench.
Benet, which won its sixth straight regional, gets Whitney Young Tuesday at the Hinsdale South Sectional, with Montini potentially next in a daunting road to Redbird Arena.
This was a big first step, a high-level game that hardly felt like only a regional final.
"It's a very tough road," Kilbride said. "This is big for us. I laid it out for the kids. We're going to have to play back to back to back tough games. I think we can beat anybody, but can we get them three in a row?"